Abstract
Furosemide a diuretic exhibits low solubility in water and low bioavailability. The purpose of this study was to determine the effect SNEDDS formation to dissolution and diffusion of furosemide. SNEDDS was made with a mixture of 66% tween 80, 26% propylene glycol, 8% oleic acid and furosemide 40mg/mL. Test for SNEDDS dissolution of the capsules was developed using USP dissolution apparatus I and compared to market products, furosemide suspenssion and furosemide powder. The medium consists of 900mL of Artificial Gastric Fluid (AGF) , phosphate buffer pH 5.8 at 37±0.5°C and stirred with a speed of 100rpm. Diffusion test of SNEDDS furosemide was conducted by using reversed rat intestinal bowel and compared to furosemide suspension and furosemide solution. The SNEDDS formulation could enhance the dissolution and diffusion of furosemide compared to the non-SNEDDS formulation
Highlights
Furosemide is a loop diuretic which is used in the treatment of edema, congestive heart failure and hypertension (Berkó et al, 2002)
Furosemide is a drug belonging to Biopharmaceutical Class System (BCS) class IV (Custodio et al, 2008), with the low dissolution rate
The purpose of this study was to determine the effect of SNEDDS against dissolution and diffusion of furosemide
Summary
Furosemide is a loop diuretic which is used in the treatment of edema, congestive heart failure and hypertension (Berkó et al, 2002). Furosemide is a drug belonging to Biopharmaceutical Class System (BCS) class IV (Custodio et al, 2008), with the low dissolution rate. Furosemide dosage forms development is being undertaken to increase solubility which eventually is expected to improve bioavailability. One such development is to create SNEDDS. SNEDDS are isotropic mixtures of oil, surfactant, cosurfactant and drugs that form an oil nanoemulsion in water when added to the water phase under slowly stirring (Nazzal et al, 2002). The purpose of this study was to determine the effect of SNEDDS against dissolution and diffusion of furosemide
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