The Dissipation Kinetics, Residue Level and Dietary Risk of Kresoxim-Methyl in Rosa roxburghii and Soil Based on the QuEChERS Method Coupled with LC-MS/MS.

Abstract

This study aimed to investigate the dissipation, residues and dietary assessment of kresoxim-methyl in the application of Rosa Roxburghii and soil field using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The results show that kresoxim-methyl in R. roxburghii samples was extracted by acetonitrile and purified by ethyl enediamine-N-propylsilane (PSA), while kresoxim-methyl in soil samples was extracted by acetonitrile and purified by octadecylsilyl solid phase dispersant (C18). 0.1% formic acid (v/v)-water-methanol solution was used as the mobile phase, LC-MS/MS exhibited a good linearity in the range of 0.001-10mgL-1. The recoveries of R. roxburghii and soil matrix were 82.48%-102.55%, and the relative standard deviation (RSD) were 1.13%-4.21%. The limit of detection (LOD) and quantification (LOQ) of kresoxim-methyl in R. roxburghii and soil samples was 0.50 and 0.60µgkg-1, respectively. The dissipation dynamics of kresoxim-methyl in R. roxburghii and soil followed the first-order kinetics, with the half-life of 4.28 and 4.41days, respectively. The terminal residual amount of kresoxim-methyl in R. roxburghii and soil samples was 0.003-1.764 and 0.007-2.091mgkg-1, respectively. The dietary intake risk assessment indicates that a risk quotient (RQ) for kresoxim-methyl based on the national estimated daily intake (NEDI) of 0.1995mg was 0.79%, suggesting that the use of kresoxim-methyl on R. roxburghii at recommended dosage was safe to consumers. This study provides the theoretical basis for guiding the rational use of kresoxim-methyl in the production of R. roxburghii.