Abstract
Aim. Investigate the disruption of geniculocalcarine tract (GCT) in different occipital neoplasm by diffusion tensor imaging (DTI). Methods. Thirty-two subjects (44.1 ± 3.6 years) who had single occipital neoplasm (9 gliomas, 6 meningiomas, and 17 metastatic tumors) with ipsilateral GCT involved and thirty healthy subjects (39.2 ± 3.3 years) underwent conventional sequences scanning and diffusion tensor imaging by a 1.5T MR scanner. The diffusion-sensitive gradient direction is 13. Compare the fractional anisotropy (FA) and mean diffusivity (MD) values of healthy GCT with the corresponding values of GCT in peritumoral edema area. Perform diffusion tensor tractography (DTT) on GCT by the line propagation technique in all subjects. Results. The FA values of GCT in peritumoral edema area decreased (P = 0.001) while the MD values increased (P = 0.002) when compared with healthy subjects. There was no difference in the FA values across tumor types (P = 0.114) while the MD values of GCT in the metastatic tumor group were higher than the other groups (P = 0.001). GCTs were infiltrated in all the 9 gliomas cases, with displacement in 2 cases and disruption in 7 cases. GCTs were displaced in 6 meningiomas cases. GCTs were displaced in all the 7 metastatic cases, with disruption in 7 cases. Conclusions. DTI represents valid markers for evaluating GCT's disruption in occipital neoplasm. The disruption of GCT varies according to the properties of neoplasm.
Highlights
The eloquent white matter tracts can be delineated by diffusion tensor imaging (DTI) in patients with intracranial neoplasm
We investigated geniculocalcarine tract (GCT) in different occipital neoplasm by DTI and assumed that diffusion indices were valid markers in evaluating GCTs’ disruption
The fractional anisotropy (FA) values of GCT in peritumoral edema area decreased (P = 0.001) while the mean diffusivity (MD) values increased when compared with the control group (P = 0.002)
Summary
The eloquent white matter tracts can be delineated by diffusion tensor imaging (DTI) in patients with intracranial neoplasm. The exact relative position between the neoplasm and white matter tracts can be investigated and prompted for dysfunction [1,2,3,4]. Diffusion indices may prompt neoplasm’s histopathology type, tumor fraction, and axonal disruption of fiber tracts since their changes provide information for the underlying microanatomic changes or pathological changes [7,8,9,10,11]. Investigating the disruption of GCT in different occipital neoplasm may assist in identifying conditions occult to structural imaging and provide relational information that is critical to clinical decision making [12,13,14,15]. GCT involved in occipital neoplasm has not been delineated well in general
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