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Abstract
Selective depletion of catechol amines (CA) in brain—with little or no depletion of 5-hydroxytryptamine-was induced by α-methyl-tyrosine methylester-HCl. Concomitant disruption of conditioned avoidance responses (CAR) was observed in cats (Shuttle box) and rats (Skinner box). Restoration of the CA levels in the brain by l-DOPA resulted in a restoration of CAR. The data support the view that the CA of the brain are essential for CAR. The relative importance of noradrenaline and dopamine is discussed.
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