Abstract
Abstract—The uptake into subcellular fractions of developing rat brain in vivo of intracerebrally injected [4‐14C]cholesterol, [24‐3H]cerebrosterol, and [24‐3H]24‐epicerebrosterol was measured for periods up to 30 days following administration. [4‐14C]cholesterol was accumulated rapidly in nuclei, nerve endings, and microsomes, more slowly in myelin and mitochondria. [24‐3H]cerebrosterol was accumulated rapidly in myelin, nerve endings, and microsomes, more slowly in nuclei and mitochondria. The uptake of [24‐3H]24‐epicerebrosterol was essentially the same as that of [24‐3H]cerebrosterol. Ratios of radioactivities of [24‐3H]cerebrosterol and [4‐14C]cholesterol accentuated the early accumulation of [24‐3H]cerebrosterol in myelin, nerve endings, and microsomes, and declining 3H:14C ratios disclosed the rapid elimination of [24‐3H]cerebrosterol and [24‐3H]24‐epicerebrosterol relative to [4‐14C]cholesterol in nerve endings and microsomes. The data suggest that the removal of [24‐3H]cerebrosterol from brain results from an enzymic metabolism of the sterol, therefore that cerebrosterol exists in brain in a dynamic state of biosynthesis and catabolism.
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