Abstract
We define the disordered boundary of the cell (DBC) as the system formed by membrane tethered intrinsically disordered protein regions, dynamically coupled to the underlying membrane. The emerging properties of the DBC makes it a global system of study, which cannot be understood from the individual properties of their components. Similarly, the properties of lipid bilayers cannot be understood from just the sum of the properties of individual lipid molecules. The highly anisotropic confined environment, restricting the position and orientation of interacting sites, is affecting the properties of individual disordered proteins. In fact, the collective effect caused by high concentrations of disordered proteins extend beyond the sum of individual effects. Examples of emerging properties of the DBC include enhanced protein-protein interactions, protein-driven phase separations, Z-compartmentalization, and protein modulated electrostatics.
Highlights
The emerging properties of the disordered boundary of the cell (DBC) makes it a global may be generated in phase-separated regions, like
We suggest that there is a boundary layer enriched with disordered domains coupled to the lipid bilayer that provides a singular environment, with properties distinct from the bulk cytoplasm or an isolated membrane model
In an isolated lipid membrane, the electric and hydrodynamic fields would show smooth continuous distributions, with gradients originating from the proximity of the charged bounding layer
Summary
The disordered boundary of the cell: emerging Abstract: Let F denote a eld and let V denote a vector space over F a pair A, A∗ of diagonalizable F-linear maps on V, each of which act properties of membrane-biorreuduncibdle intrinsically tridiagonal fashion. Such a pair is called a Leonard pair. Disordered proteins there exists an automorphism of the endomorphism algebra of V that is unique, and called the duality A ↔ A∗.
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