Abstract

Thirty years ago, Miller and Mitchell described the bone-marrow origin of antibody-forming cells and the thymic origin of the help needed to activate the bone-marrow-derived antibody formation. Since then, there has been a continuous stream of discovery in Australia, from Zinkernagel and Doherty's description of MHC-restricted antigen recognition to Goodnow's dissection of the maturation and tolerization of antigen-specific B cells. All of these discoveries, and many more described in the text, contribute to the modern synthesis in immunology.

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