Abstract
The discovery of T cell-B cell cooperation.
Highlights
The carrier effect in the secondary response to hapten-protein conjugates
Together these properties opened the way to an easy mouse serology; for a while, it became so widely used that the European Journal of Immunology accepted its name as not requiring further explanation
An individual primed by injection of a hapten–protein conjugate makes a full secondary anti-hapten antibody response only to the same conjugate, but not to the same hapten conjugated to another protein
Summary
The carrier effect in the secondary response to hapten-protein conjugates. An individual primed by injection of a hapten–protein conjugate makes a full secondary anti-hapten antibody response only to the same conjugate, but not to the same hapten conjugated to another protein. This finding suggested to us that two cells might be involved, one recognizing the hapten and the other the carrier protein.
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