The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Abstract

Virtual and high-throughput screening identified imidazo[1,2-a]pyrazines as inhibitors of B-Raf. We describe the rationale, SAR, and evolution of the initial hits to a series of furo[2,3-c]pyridine indanone oximes as highly potent and selective inhibitors of B-Raf.