Abstract
The article studies the reactions of biochemical, hematological, pathomorphological, immunological and ultrastructural changes in the organisms of laboratory animals that were subjected to chronic dioxin poisoning at threshold doses were studied. There were hold toxicological experiments on white rats of both sexes weighing 155–215 g in order to detect threshold doses. For two months, 2,3,7,8-tetrachlorodibenzo-para-dioxin (2,3,7,8- TCDD) in amounts corresponding to 1/100 and 1/200 LD 50. After each decade, some of the animals were euthanized and weighed to calculate the mass coefficient of internal organs. The obtained data comparison revealed no statistically significant changes in organ. Continued observation of animals in the experiment for up to two months, characteristic intoxication 2,3,7,8-TCDD clinical signs did not give. The correlation dependence of the minimum effective doses of 2,3,7,8-TCDD, namely 1/400 of LD50 with LD50, was determined. The obtained threshold dose of dioxin can be recommended as the basis for the normalization of dioxin in the Russian agro-industrial complex. There were determined biochemical, hematological and ultrastructural changes in the body of animals exposed to chronic poisoning of 2,3,7,8-TCDD in doses of 1/200, 1/300 of LD50. The article describes a statistically significant dependence of the respiratory activity of the liver mitochondria in laboratory animals (white rats and rabbits) on chronic poisoning with threshold doses of various degrees. Based on laboratory animals’ experiments, threshold concentrations are determined and the maximum permissible levels of dioxin in the feed of some animals are tentatively calculated.
Highlights
The concentration of dioxin in tissues in the organs of farm animals in agricultural countries was lower than in industrial countries; So, in northern Vietnam – 145 ng/kg versus 1200 ng/kg in some areas of the United States
Assessment of the degree of exposure to a toxicant in certain environments is based on the following basic principles: A) Each toxicant has a quantitative threshold of action; doses of the toxicant will be considered harmless at the threshold concentration level
We analyzed the change in the respiratory response to adenosine diphosphate (ADP) of the liver mitochondria of 2,3,7,8-TCDDintoxicated animals polarographically recorded, we examined the “state 4” before and after the administration of ADP in the respiratory reaction of isolated liver mitochondria of animals with various degrees of chronic intoxication with doses of 2,3,7,8TCDD, judging by their nature, close to the threshold
Summary
The concentration of dioxin in tissues in the organs of farm animals in agricultural countries was lower than in industrial countries; So, in northern Vietnam – 145 ng/kg versus 1200 ng/kg in some areas of the United States. Most researchers including Zheltov V.A. study the supply of dioxin from contaminated farmland to feed and in several studies reflects the level of dioxin replenishment in the components of the environment, its traffic along the trophic pathways water – feed – agricultural products – consumer. The term dioxins itself is often used for a number of chemically related lipophilic compounds (polychlorinated dibenzo-para-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF), including some dioxin-like polychlorinated biphenyls (PCBs) with similar toxic properties. Emergency situations at chemical synthesis plants cause the effects of emissions with a high concentration of dioxin and pollute local areas. The source of dioxins in the soil cover is atmospheric precipitation containing dioxins, transfer of toxic wastewater and sludge from sewage treatment plants to agricultural fields, dumping of sludge-polluted water onto pastures and excessive use of pesticides, and fertilizer contaminated with a toxicant. The issue of control and regulation of this technogenic toxicant in agricultural production facilities has been raised with varying success in the sciences within recent decades
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