The differential effect of socio-economic status on body mass index among Aboriginal children & adolescents

Abstract

11 -hydroxysteroid dehydrogenase type 2. Sevenweek-old male tg mice and their wild type (WT) littermates (n = 6—9/group) were fed ad libitum a control diet (14.3% energy from fat, 25.5% from protein) or an isoenergetic high-fat diet (HFD; 43.0% energy from fat, 25.5% from protein) for 18 weeks. Body weight and food intake were measured weekly. Serum corticosterone levels were quantified after 10 weeks of feeding, and body composition and bone parameters were assessed at endpoint. As animals were fed an isoenergetic diet, changes in body weight and body composition did not differ between the four groups. Both WT and tg mice fed the HFD had higher serum corticosterone levels than WT or tg control mice (pooled measures: 386± 35 nM for HFD vs. 285± 36 nM for control diet; p = 0.054). Corticosterone levels in WT and tg mice fed the same diets (either HFD or control) were similar. At endpoint, WT mice fed a HFD had significantly lower BMD than both WT mice receiving the control diet (0.058± 0.001 g/cm2 vs. 0.064± 0.0007 g/cm2; p < 0.005) and tg animals fed the HFD (0.058± 0.001 g/cm2 vs. 0.063± 0.001 g/cm2; p < 0.005). Similarly, WT mice on HFD exhibited lower BMC than WT control mice (0.64± 0.02 g vs. 0.74± 0.02 g; p < 0.005) and tg mice receiving the HFD (0.64± 0.02 g vs. 0.72± 0.02 g; p < 0.005). Neither BMD nor BMC differed significantly between tg control and tg HFD mice. We conclude that high dietary fat intake negatively affects bone mass via glucocorticoid signalling in osteoblasts and osteocytes.