Abstract
Simultaneous intraluminal pressure measurements were made in separate colonic segments of sixteen human subjects. The amount and characteristics of the basal and phasic pressures in different parts of the colon are described. The effects of selected drugs upon the intraluminal pressure are also noted. Small doses of Mecholyl and neostigmine selectively enhanced the phasic activity of the proximal colon, but did not affect the distal colon. Large doses of these drugs increased phasic activity in both the proximal and distal colon. Urecholine consistently increased both proximal and distal colonic phasic activity. Serotonin stimulated the proximal colon, but depressed distal colonic motility. Elorine depressed spontaneous and drug-induced phasic activity in both areas. The difference in the effect of autonomic agents on the ascending and descending colon suggest that the concentration of cholinesterase in the distal colon is greater than that of the proximal colon.
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