Abstract
Diagnostic work-up of the jaundiced infant for to the early diagnosis of biliary atresia should include (1) the quantitative determination of LP-X, an abnormal, low-density, lipoprotein found only in severe cholestasis; (2) the use of cholestyramine, a nonabsorbable resinous copolymer which binds bile acids in the G.I. tract, thereby, promoting their excretion; and (3) a modified 131I-rose bengal excretion test. This protocol has been useful in differentiating between jaundiced neonates with neonatal hepatitis and biliary atresia.
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