Abstract
Background: Premedication is the administration of medication before anaesthesia. It is used to prepare the patient for anaesthesia and to provideoptimal conditions for surgery.
 Methods: The study of oral premedication dose of clonidine in spinal surgery at different time was conducted on sixty ASA grade-1 patients of eithersex between 20 to 60 years of age undergoing elective spine surgery. This study was performed after approval from ethics committee of the institute.Informed consent was obtained from each patient.
 Results: The total induction dose of propofol required for the induction of the patient is 2-2.5 mg/kg body weight. In our study the average weightof the patient in group-1 was 58.83 kg and in group-2, average weight of the patient was 54.77 kg. The total average weight of patient in the study was 56.80 kg. Thus the total induction dose of propofol required should have been 117.66 mg in group-1, 109.54 mg in group-2 and 113.6 mg in averagetotal.
 Conclusion: In conclusion this study establishes that the premedication with tab. clonidine 200µg (As tab. clonidine is available in 100µg) 90 minutebefore the surgery or 3.5 hour before the surgery reduced induction dose of propofol.
 Keywords: Clonidine, Propofol, Spine
Highlights
Premedication[1] is the administration of medication before anaesthesia
The study of oral premedication dose of clonidine in spinal surgeryat different time was conducted on sixty ASA grade-1 patients of either sex between 20 to 60 years of age undergoing elective spine surgery
The total induction dose of propofol required for the induction of the patient is 2-2.5 mg/kg body weight
Summary
Premedication[1] is the administration of medication before anaesthesia. It is used to prepare the patient for anaesthesia and to provideoptimal conditions for surgery. The choice of premedication depends upon various factors like type of surgery, age of the patient, choice of the anaesthesia and as more and more patients are going in for the day care surgery, the use of premedication is declining as the patients are reporting late on the day of surgery. It was observed that only 37.2% of the patients posted for surgery get normal premedication, in 9.7% no premedication was given and in rest of the patients the premedication time was not appropriate. Premedication aspects of rest of the patients were overlooked or were not properly followed.[2]
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