The differences of interleukin 6 expression between titanium and stainless steel kirschner wire applied in wistar rat tibial bone

Abstract

Implants are widely used for orthopaedic applications such as fixing fractures, repairing non unions, obtaining a joint arthrodesis, total joint arthroplasty, spinal reconstruction, and soft tissue anchorage. Loosening cases in implant usage usually caused by bone resorption. Osteoclast have a pivot role in bone resorption. IL-6 is secreted by osteoblast as a response to metal ion. The purpose of this study is to know the differences between IL-6 express in tibial bone wistar rat applied titanium and stainless steel k-wire.This is an experimental study with Randomized post-test only control group design. Collected thirty wistar rat, divided into three groups, which are P0 treated with burr only in tibial bone, P1 treated with applied titanium k-wire Ø 1,25 in tibial bone,  P2 treated with applied stainless steel k-wire Ø 1,25 in tibial bone. In the days 21 immunohistochemistry test was conducted and meassured the expression of IL-6 on osteoblast.Statistic analysis with  One Way Anova, The results shows p = 0,000. That means the differences of expression between three groups is significant (p<0,05). This shows that this difference is statistically significant.This study conclude that there is a significance different expression of IL-6 between rat that applied titanium implant and stainless steel implant.   Â