Abstract
BackgroundAlpha-fetoprotein (AFP)–producing gastric cancer is a distinct type of gastric cancer with a high incidence of liver metastasis. c-Met is considered to play an important role in liver metastasis of gastric cancer.ObjectiveThe purpose of this study was to compare the expression of c-Met in AFP-producing gastric cancer and gastric cancers not producing AFP.MethodsWe evaluated 23 patients with AFP-producing gastric cancer (AFP+) and 18 patients with common gastric cancer (AFP–) were evaluated for c-Met expression using immunohistochemical analysis.ResultsThe incidence of c-Met expression in 2 groups was the same (P > 0.05), but the AFP+ group had a higher strong positive rate of c-Met expression than the AFP– group (P < 0.01).ConclusionThe higher expression of c-Met might be the reason for the high incidence of liver metastasis in AFP-producing gastric cancer.
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