Abstract
Background: H. pylori gastritis can be related to people with obesity and metabolic syndrome. The mechanism underlying the relationship between them is suspected to be caused by adipocytokine called resistin. Objective: to analyze the difference level of resistin between positive and negative H. pylori gastritis patients and their relationship with nutritional status.Method: This cross sectional study was done in the Gastroenterology department of General Hospital Adam Malik, Medan, from May to October 2019. Patients with gastritis diagnosed by endoscopy underwent rapid urease test (RUT), resistin, albumin, hemoglobin tests, also body mass index (BMI) and waist circumference (WC) were measured.Results: Sixty gastritis patients found by endoscopic examination, 29 (48.33%) was H. pylori positive and 31 (51.67%) was negative. No significant differences were found between BMI, WC, and albumin against H. pylori gastritis with p values 0.099, 0.055, and 0.528, respectively. Hemoglobin was found significant with a p 0.009. The mean resistin in the positive H. pylori group was 7.62 ng/ml while the negative was 3.23 ng/ml, and statistically significant (p 0.001). There was a strong positive correlation between resistin levels with BMI and WC (BMI p 0.01, r 0.577; WC p 0.001, r 0.592).Conclusion: Resistin levels in gastritis with H. pylori positive are higher than H. pylori negative, body mass index and waist circumference have a strong relationship with resistin levels in patients with positive H. pylori gastritis, hemoglobin is lower in H. pylori positive than negative gastritis.
Highlights
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A statistical analysis of the employment relationship with positive and negative H. pylori was IRXQG WR EH LQVLJQL¿FDQW ZKLOH D VWDWLVWLFDO DQDO\VLV of the educational level with H. pylori was found to EH VLJQL¿FDQWO\ GL൵HUHQW IURP WKH UHVXOWV RI S (p < 0.05)
To determine the mechanism underlying the relationship between obesity and H. pylori gastritis, we examined the serum concentration of resistin in the same subject previously analyzed for the relationship of body mass index (BMI) with H. pylori gastritis, and found that the prevalence of H. pylori gastritis increased when resistin levels increased, using the Mann Whitney test found D VLJQL¿FDQW PHDQ GL൵HUHQFH S RI UHVLVWLQ levels in patients with positive and negative H. pylori gastritis
Summary
Adipose tissue in obesity have a biological role, play a role in triglycerides metabolic processes and acts as an endocrine gland that secretes various cytokines and peptide hormones which play a role in regulating the balance of body weight DQGHQHUJ\PHWDEROLVPEXWDOVRLQWKHLQÀDPPDWRU\ process. Some of these substances are adiponectin, OHSWLQUHVLVWLQLQWHUOHXNLQWXPRUQHFURVLVIDFWRUĮ 71)Į 4 Resistin is thought to have a role in the condition of insulin resistance.[5]. The mechanism underlying the relationship between them is suspected to be caused by adipocytokine called resistin.
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