The difference of event related potential between the male university students with higher and lower CCK-8 levels under task of sensation seeking for finding a new face

Abstract

Objective To observe the brain event-related potential(ERP) differences between high and low CCK-8 groups who induced by feeling seeking task to found a new face, and try to find a new way to treat addiction. Methods 100 boys were d rawn from the new students in Maritime University in Dalian city. High and low CCK-8 Groups were divided according to the CCK-8 level ranking by Quartile method((176.80±118.05)mmol/L, (43.13 ±13.35)mmol/L; t=3.90; P=0.00).25 boys in each group, age ranged 19-21 years old, and they were right-handed and with normal vision. Methods ERP induced by the task of sensation seeking to fond a new face, and ERP result was recorded. Subjects behaviors were evaluated by error rate and reaction time for the new face task stimuli, sensation seeking scale scores between the higher and lower CCK-8. SPSS 15.0 soft ware was used in the data analysis. Behavior results were analyzed by t test, and the three mixed factors interaction of the areas of the brain (left, right)×lobes (frontal region, central, parietal area)×groups (high, low CCK-8) with repeated measures analysis of variance. Results P300 was induced by new face finding task.Main effects of brain areas was significant (F(1.60, 35.21)=6.61, P=0.01); and lobes main effect was significant (F(1.51, 33.17)=3.41, P=0.26). Significant interaction was found between the brain lobes and the brain regions(F(2.01, 44.12)=13.27, P=0.00); and interaction effect was significant between the lobes, areas and groups(F(2.01, 44.12)=2.97, P=0.06). Conclusion CCK8 can influence the sensation seeking, and the higher levels of CCK8, the higher power of sensation seeking. Key words: CCK-8; A new face finding; Boys; Sensation seeking scale; EREP