Abstract
Introduction Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris. Methods This is an analytical observational cross-sectional study. Sample subjects were patients with acne vulgaris who met the inclusion criteria. Enzyme-linked immunosorbent assay (ELISA) study was applied to measure IL-19 serum. Result Analysis test found statistically significant difference between IL-19 serum concentration of group of patients with mild acne vulgaris and that of group of patients with severe acne vulgaris. Moreover, analysis revealed significant difference between IL-19 serum concentration of group of patients with moderate acne vulgaris and that of group of patients with severe acne vulgaris. Conclusions There are differences in serum levels of IL-19 on the severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris.
Highlights
It is stated that inflammation continuous to happen in early stage and late stage of acne vulgaris [3]; the inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris [4]
Propionibacterium acnes stimulates keratinocytes through the Toll-like receptors (TLRs) to produce proinflammatory cytokines
The inclusion criteria include subjects between the ages of 16 and 30 years clinically diagnosed with acne vulgaris who were willing to participate in the research and to fill in a questionnaire and a statement of willingness
Summary
Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris. Acne vulgaris is a multifactorial disease which is associated with pilosebaceous follicle and results in inflammatory and noninflammatory lesions [1]. There is no study about IL-19 cytokines related to acne vulgaris or acne vulgaris severity
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