Abstract
Abstract: Akar kuning (Fibraurea tinctoria Lour.), an original plant from Kalimantan, is often used by the community as traditional medicine. Previous studies showed that akar kuning contains active compounds such as alkaloids, flavonoids, saponins, and terpenoids that have antibacterial properties. This study aims to analyze the difference in antibacterial potency of the infusion of akar kuning against the growth of Shigella dysenteriae (S. dysenteriae) and Salmonella typhi (S. typhi) in vitro. This was a true experimental study with a post-test method only with control group design using the infusion of akar kuning with concentrations of 16%, 32%, and 64%, 5 µg ciprofloxacin as the positive control and aquadest as the negative control. The data were analyzed using the One-Way ANOVA test, LSD’s Post-hoc test, and independent T test with a 95% of confidence level. This study showed that the higher the concentration of the infusion of akar kuning, the larger the inhibition zone of the infusion at the concentration of 64% had a larger inhibition zone for S. typhi (16,32 mm) than S. dysenteriae (15,59 mm). However, there was no statistical difference in antibacterial potency of the infusion of akar kuning against S. dysenteriae and S. typhi. Keywords: antibacterial potential, infusion, akar kuning, Fibraurea tinctoria Lour., Shigella dysenteriae, Salmonella typhi
Highlights
The province of South Kalimantan is mostly composed by rivers and wetlands
We found no studies assessing differences in antibacterial potency of the infusion of akar kuning’s root against these bacteria
The results demonstrated that the minimum inhibitory concentration (MIC) for the infusion to inhibit the growth of both bacteria was 16%
Summary
The province of South Kalimantan is mostly composed by rivers and wetlands. The community often uses fresh water for daily activities. Bacteria causing systemic infection and gastrointestinal infections such as Shigella dysenteriae (S. dysenteriae) and Salmonella typhi (S. typhi) are frequently found in polluted waters.[1] S. dysenteriae causes basilary dysentery and S. typhi causes mild gastroenteritis to typhoid fever.[2] According to Riset Kesehatan Dasar (RISKESDAS), the prevalence of diarrhea in Indonesia and in South Kalimantan are about 8% and 7%, respectively.[3]. Antibiotic fluoroquinolone group such as ciprofloxacin is often used to treat S. dysenteria and S. typhi infection. Some studies showed the increased number of resistance against these bacteria.[4,5,6]
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