The Difference Effect of Adolescent and Adult Pregnancy on Apoptosis Index of Neuron Cells

Abstract

Context: Adolescent who are pregnant will experience depression due to physical and mental unpreparedness that affects cortisol which will reduce the secretion of Brain Derived Neutrotrophic Factor, so that it will increase the index of apoptosis of brain neuron cells. This study aims to determine differences in the influence of adolescent and adult pregnancy on the index of apoptosis of brain neuron cells. The study used true laboratory experimental design with post test only control group design using animals tried to mice Mus musculus. The experimental group was divided into two groups: the control group or the adult pregnancy, and the treatment group or the teenage pregnancy group. The brain dissection of the newborn Musculus mice was taken and calculated the number of neuron cell apoptosis index using Immunohistochemical Tunnel. There were significant differences in the brain neuron cells apoptosis index with a value of p = 0.01 (mean 4.13 + 2.52 in the treatment group, 2.81 + 1.43 in the control group). There were significant differences in apoptosis index of brain neuron cells in the newborn Mus musculus mice in teenage pregnancy and the control group.