The difference between induction and maintenance dosages of propofol for general anesthesia in patients with and without sleep quality disorder

Abstract

ObjectiveThis study was conducted to compare propofol dose requirements between patients with and without sleep quality disorder (SQD) in order to achieve the same depth of anesthesia. MethodsIn this comparative study, adult patients who were candidates for elective cataract surgery under general anesthesia in American Society of Anesthesiologists (ASA) class I or II were included. Using a validated questionnaire, patients were divided into two groups with Pittsburgh Sleep Quality Index (PSQI) higher and lower than five. Pre-induction with midazolam 0.02 mg/kg and fentanyl 2 µg/kg was administered 3 min before induction. Induction and 1-hour maintenance doses of propofol to achieve and maintain bispectral index score (BIS) 40–60 were measured and compared in the two groups. ResultsSeventy patients, 47 of which (67.1%) were female, with the mean age of 63.83 ± 10.67 years were enrolled; 35 in SQD group and 35 in normal group. Baseline and demographic characteristics were not significantly different between the two groups. BIS score after pre-induction was significantly lower in SQD group compared with normal group (p = 0.002). Propofol dose at the time of induction and also 1 hour after induction was significantly lower in SQD group compared to normal group (p < 0.001). Total dose of propofol required was significantly lower in SQD group (209.26 ± 81.02) compared to normal group (342.91 ± 100.59) (p < 0.001). Based on the unstandardized Beta of multivariable linear regression model, mean total propofol requirement in SQD group was 113.43 mg less than normal group (p < 0.001). ConclusionIn the current study, induction and maintenance doses of propofol for general anesthesia were significantly lower in patients with SQD, in comparison with normal patients.