Abstract
Quercetin reduces blood pressure in hypertensive, but not normotensive individuals. Ex vivo tissue has implicated NADPH oxidase signalling and ROS formation in the mechanism of action in vascular smooth muscle, however there has been no assessment of the role of the endothelium in the anti-hypertensive effects of quercetin. This study describes an endothelial cell model of hypertension and its use to probe the anti-hypertensive effects of quercetin. Angiotensin II (100 nM, 8 h) rendered Human Umbilical Vein Endothelial Cells (HUVEC) hypertensive, characterised by decreased nitric oxide availability (15±4%, p In summary, quercetin restores nitric oxide:superoxide imbalance in hypertensive endothelial cells to control levels, in a PKC-independent manner, with down-regulation of p47phox also observed. No effects of quercetin upon control cells are reported.
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