Abstract
Top-down modulation of sensory perception regulates the strength of sensory input enabling adaption of behavioral responses. The horizontal limb of the diagonal band of broca (HDB) participates in the modulation of these processes by shaping olfactory bulb (OB) output. It remains, however unknown, if HDB-OB projections alone can mediate these complex behavioral effects, or if additional brain regions, synaptically connected to HDB are also needed. We show that HDB-silencing disrupted odor habituation in freely moving mice and led to reduced odor-evoked Ca 2+ -responses in bulbar glomeruli, underscoring HDB’s role in odor response modulation. Furthermore, selective, light-mediated silencing of HDB-OB afferents impaired olfactory-mediated habituation and social habituation/discrimination. Mono-transsynaptic tracing studies indicated a robust HDB innervation from the paraventricular nucleus (PVN) suggesting a novel tri-synaptic PVN-HDB-OB axis implemented in the modulation of these behaviors. Thus, HDB-OB projections constitute a top-down pathway for both, olfactory-mediated habituation and social habituation/discrimination behaviors.
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