Abstract
Aim The aim of this study was to evaluate the diagnostic value of serum ischemia-modified albumin (IMA) levels in patients presenting to the emergency department with acute abdominal pain and its use in differentiating acute surgical abdomen. Methods This single-center prospective cross-sectional study included 334 adult patients who presented to the emergency department. These consisted of 194 patients (Group 1) with nontraumatic abdominal pain commencing in the preceding week, who were definitely diagnosed and either hospitalized in a specific department or planned for discharge, and a control group of 140 patients (Group 2). Results The mean IMA value of the patients diagnosed with acute appendicitis was statistically significantly higher than that of the control group. The mean IMA value of the patients diagnosed with acute appendicitis, ovarian pathologies, and gastritis-peptic ulcer was statistically significantly higher than that of the nonspecific abdominal pain group. Conclusion Serum IMA levels can be used as a diagnostic marker in patients with acute appendicitis. Furthermore, serum IMA levels in patients presenting to the emergency department with abdominal pain may be indicative of patients requiring surgery or of complicated cases, particularly in terms of acute appendicitis and ovarian pathologies.
Highlights
Acute abdominal pain is a symptom of unknown cause commencing within the previous seven days and indicates a surgical or medical emergency
Several biochemical markers, including D-dimer, C-reactive protein (CRP), plasma pentraxin-3, and the neutrophil/leukocyte ratio (NLR), have been investigated in terms of the differential diagnosis of patients with acute abdominal pain, in cases requiring surgical intervention. ese parameters have been defined as markers of surgery requirements in patients with undiagnosed acute abdominal pain
Another study described CRP levels as a useful parameter for differentiating patients requiring operative or nonoperative treatment among individuals with nonspecific abdominal pain. e plasma neutrophil/leukocyte ratio (NLR) and pentraxin-3 levels have been reported to increase in patients with acute appendicitis and as being of potential use at differential diagnosis [5,6,7,8]
Summary
Acute abdominal pain is a symptom of unknown cause commencing within the previous seven days and indicates a surgical or medical emergency. Various markers have been described as capable of use in the differential diagnosis of patients with abdominal pain [4]. Several biochemical markers, including D-dimer, C-reactive protein (CRP), plasma pentraxin-3, and the neutrophil/leukocyte ratio (NLR), have been investigated in terms of the differential diagnosis of patients with acute abdominal pain, in cases requiring surgical intervention. D-dimer elevation in patients with acute abdominal pain has been reported as a potential marker with high sensitivity for surgical pathologies requiring laparotomy. Another study described CRP levels as a useful parameter for differentiating patients requiring operative or nonoperative treatment among individuals with nonspecific abdominal pain. E plasma neutrophil/leukocyte ratio (NLR) and pentraxin-3 levels have been reported to increase in patients with acute appendicitis and as being of potential use at differential diagnosis [5,6,7,8] Another study described CRP levels as a useful parameter for differentiating patients requiring operative or nonoperative treatment among individuals with nonspecific abdominal pain. e plasma neutrophil/leukocyte ratio (NLR) and pentraxin-3 levels have been reported to increase in patients with acute appendicitis and as being of potential use at differential diagnosis [5,6,7,8]
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