Abstract
e22232 Background: We have selected glutathione peroxidase 3 (GPx3) as a specific candidate that is down-regulated in patients with lung cancer. In this study, we examined the diagnostic value of serum GPx3 which is extracellular protein and readily detectable in blood. Methods: We collected serum samples from 342 patients with lung cancer and 126 controls (normal healthy people and patients with benign diseases or other malignancies). We measured serum GPx3 levels using the enzyme-linked immunosorbent assay. Results: Mean serum GPx3 levels were significantly lower in the patient group as compared with the control group (10.1 ± 5.0 mg/mL vs. 13.0 ± 5.8 mg/mL, P<0.001). In addition, mean serum GPx3 levels were significantly lower in the patients without metastasis as compared with those with metastasis (9.6 ± 4.5 mg/mL vs. 10.7 ± 5.7 mg/mL, P=0.051). Furthermore, mean serum GPx3 levels had a significant correlation with initial treatments (P<0.001). In other words, mean serum GPx3 levels were significantly...
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