The Diagnostic Value of Monocyte Count/HDL Cholesterol Ratio as a New Marker in Diabetic Retinopathy

Abstract

Abstract Background Diabetes mellitus is a set of metabolic diseases characterized by chronic hyperglycemia as a consequence of lack in insulin action, secretion, or both. All of which lead to long-term damage and dysfunction of different organs predominantly the eyes, kidneys, nerves, heart, and blood vessels. Aim of the Work The aim of the study is to investigate the diagnostic value of MHR in diabetes and whether it can be utilized as an indicator of diabetic retinopathy. Patients and Methods This study was a case control study on 100 patients attending diabetes outpatient clinic at Ain shams university hospital 30 male, 70 female. 50 patient with diabetic retinopathy and 50 patient without retinopathy to detect the MHR in each group and to detect whether it can be utilized as an indicator of diabetic retinopathy. Results In this study there is a significant correlation between diabetic retinopathy and MHR, MHR being higher in patient with diabetic retinopathy, with a cut-off level of > 0.01 with 74% sensitivity and 64% specificity. Our study showed a significant relation between long standing duration of diabetes mellitus and diabetic retinopathy. Also there was significant relation between diabetic retinopathy with high glycemic profile with fasting blood sugar and 2 hour post prandial blood sugar and Hba1c. The study also show that there is no significant relation between diabetic retinopathy and weight, height, BMI. Conclusion Diabetic retinopathy (DR) is a major complication of diabetes mellitus (DM), which remains a leading cause of visual loss in working-age populations. MHR being higher in patient with diabetic retinopathy. And can be it can be utilized as an indicator of diabetic retinopathy.