The diagnostic value of enhanced magnifying endoscopy for early gastric cancer

Abstract

Objective To investigate the diagnostic value of magnifying endoscopy enhanced by acetic acid-indigo carmine mixture （ME-AIM） and magnifying endoscopy enhanced with narrow-band ima- ging （ME-NBI） in the diagnosis of early gastric cancer （EGC）. Methods A total of 317 focal gastric le- sions, determined by WLE on the basis：of：the assessment of mucosal shape and color, were further character- ized with ME-NBI and ME-AIM. The accuracy of each endoscopic method for the diagnosis of EGC was com- pared with the pathological results as the g0td standard. Results For the diagnosis of EGC, the sensitivity, specificity, and accuracy of ME-NBI were 100.0% （ 11/11 ）, 99.7% （305/306） and 99.7% （316/317） respectively; those of ME-AIM were 90. 9% （ 10211）, 99.0% （303/306） and 98.7% （313/317） respec- tively; those of WLE were 72.7% （8/11）, 88,2% （270/306）and 87.7% （278/317）respectively. The specificity and accuracy of both ME-NBI and MEzAIM were significantly better than those of WLE （P 〈 0. 05）. Both ME-NBI and ME-AIM had higher sensitivity than WLE, but the difference was not significant （ P 〉 0. 05 ）. ME-NBI was not superior to ME-AIM in the diagnosis of EGC （ P 〉 0. 05 ）. Conclusion WLE is still a useful modality in screening EGC. Both ME-NBI and ME-AIM can improve the diagnostic accuracy in comparison with WEE, but ME-NBI is not superior to ME-AIM in identifying EGC. Key words: Early gastric cancer; Magnifying endoscopy; Acetic acid; Indigo carmine