The diagnostic value of endoscopic ultrasonography for pancreatic neuroendocrine tumors

Abstract

Objective To study the diagnostic value of endoscopic ultrasonography(EUS)for pancreatic neuroendocrine tumors (pNETs) by comparing EUS with computed tomography (CT), ultrasonography, magnetic resonance imaging (MRI) and positron emission tomography/computed tomography (PET/CT). Methods Data of 70 pNETs cases (a total of 77 lesions) confirmed by pathological diagnosis from July 2012 to March 2016 in Shanghai Cancer Center of the Fudan University were retrospectively studied. Among the cases, 53 cases (a total of 60 lesions) were confirmed by surgical pathology and their results of EUS, abdominal ultrasonography, CT, MRI and PET/CT were compared before surgery. Results A total of 76 lesions were detected by EUS, in which 32 lesions less than 2 cm were tested by HI ZOOM high definition amplification, qualified elastography images of 49 lesions were obtained, 42 solid lesions or solid components were also tested by Fine Flow, and 6 cases were tested by 3D imaging. Diagnostic rates of lesions by EUS, ultrasonography, CT, MRI and PET/CT were 98.33% (59/60), 61.11%(33/54), 89.47%(51/57), 76.00%(19/25) and 78.38%(29/37), respectively. For lesions less than 2 cm, diagnostic rates by these examinations were 96.30% (26/27), 47.83%(11/23), 76.00%(19/25), 54.55%(6/11) and 58.82%(10/17), respectively. Accuracy rates of EUS, ultrasonography, CT, MRI and PET/CT in the location of these lesions were 91.67%(55/60), 51.85%(28/54), 80.70%(46/57), 72.00%(18/25) and 75.68% (28/37), respectively. Conclusion Combined with Fine Flow, HI ZOOM high definition amplification and elastography, EUS is superior to standard imaging for pNETs, especially for lesions less than 2 cm. Key words: Endoscopic ultrasonography; Diagnosis; Pancreatic neuroendocrine tumors