The diagnostic value of capsule endoscopy for asymptomatic NSAID–induced enteropathy

Abstract

Objective To study the diagnostic value of capsule endoscopy for asymptomatic non–steroid antiinflammatory drugs(NSAID)–induced enteropathy. Methods A total of 110 health exam cases(38 cases taking NSAID orally)were recruited to the study and underwent capsule endoscopy. The incidence of small intestine lesion of NSAID takers and non–NSAID takers, that of those whose medication time longer than 3 months and less than 3 months, and who took low dose asprin and who took non–asprin NSAID were compared. The location of mucosal lesions and recovery status were followed up. Results The incidence of small intestine lesions was significantly different between NSAID group(55.3%, 21/38) and non–NSAID group(5.6%, 4/72)(P<0.01). The incidence of small intestine lesion was significantly higher in the over–three–month–medication group than in the less–than–three–month group(7/24 VS 4/14, P=0.01). The incidence of small intestine lesions was also significantly higher in the non–asprin group than asprin group(11/14 VS 10/24, P<0.05). The ulcerative lesions were predominantly located in the ileum(10/11), while the erosive lesions were predominantly found in the jejunum(8/10). Eight ulceration cases recovered after stopping taking NSAID or the use of rebamipide. Four erosion cases recovered after the use of rebamipide. Conclusion Capsule endoscopy is of favourable diagnostic and therapeutic value for asymptomatic NSAID–induced enteropathy. Key words: Small intestine; Non–steroid antiinflammatory drugs; Aspirin; Capsule endoscopy; Endoscopy