Abstract
Background: Diagnosis of serious bacterial infections (SBI) in young children is a difficult task for pediatricians. Objective: Our aim was to determine regularities of the change of hemogram indicators and serum markers of inflammation for the differential diagnostics of SBI in children under the age of 5 years. Methods: The comparative retrospective study is carried out. We analyzed diagnostic characteristics of laboratory markers of SBI during the examination of 306 children with pyretic fever. We determined the number of leukocytes, neutrophils, immature granulocytes, reticulocyte hemoglobin equivalent, C-reactive protein (CRP) and procalcitonin. Results: The study of CRP content has the greatest diagnostic accuracy at differential diagnostics of SBI in children with infectious fever at the height of disease. It is established that the positive result of CRP ( 37 mg/L) increases the probability of SBI in patient from 17.6% to 70%, and the negative result (< 37 mg/L) reduces the probability of SBI to 4%. Conclusion: Cut-off values of the laboratory parameters obtained in our study can be used when assessing the post-test probability of SBI in children with infections accompanied by pyretic fever.
Highlights
Diagnosis of serious bacterial infections (SBI) in young children is a difficult task for pediatricians
We determined the number of leukocytes, neutrophils, immature granulocytes, reticulocyte hemoglobin equivalent, C-reactive protein (CRP) and procalcitonin
It is established that the positive result of CRP (у 37 mg/L) increases the probability of SBI in patient from 17.6% to 70%, and the negative result (< 37 mg/L) reduces the probability of SBI to 4%
Summary
Диагностика тяжелых бактериальных инфекций (ТБИ) у детей младшего возраста остается трудной задачей. Цель исследования: установить закономерности изменения показателей гемограммы и сывороточных маркеров воспаления для дифференциальной диагностики ТБИ у детей в возрасте до 5 лет. ТБИ при обследовании 306 детей с фебрильной лихорадкой. Результаты: наибольшей диагностической точностью при дифференциальной диагностике ТБИ у детей с инфекционной лихорадкой в разгар заболевания обладает исследование содержания СРБ. Заключение: пороговые значения (cut-off) лабораторных показателей, полученные в настоящей работе, могут быть использованы при оценке посттестовой вероятности ТБИ у детей с инфекциями, сопровождающимися фебрильной лихорадкой. Е. Диагностическая значимость показателей гемограммы и сывороточных маркеров воспаления при тяжелых бактериальных инфекциях у детей младше 5 лет. ОБОСНОВАНИЕ Инфекции, сопровождающиеся фебрильной лихорадкой, служат причиной 20–35% всех обращений к врачу и госпитализаций детей младшего возраста [1, 2].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
