The diagnostic performance of ultrasonographic optic nerve sheath diameter and color Doppler indices of the ophthalmic arteries in detecting elevated intracranial pressure

Abstract

ObjectivesTo assess the diagnostic accuracy of ultrasonographic optic nerve sheath diameter (ONSD) measurement and color Doppler indices of the ophthalmic arteries in detecting elevated intracranial pressure (ICP). Patients and methodsA total 60 patients with (cases, n=30) and without (controls, n=30) acute clinical and computed tomographic findings of elevated ICP due to intracranial mass/hemorrhage were recruited from a teaching hospital. The mean binocular and maximum ultrasonographic ONSDs, as well as the mean binocular Doppler ultrasound waveform indices of the ophthalmic arteries including pulsatility index (PI), resistive index (RI), end-systolic velocity (ESV), peak systolic velocity (PSV) and end-diastolic velocity (EDV) were compared between the two groups. ResultsCompared to controls, the case group had significantly higher mean binocular ONSD (5.48±0.52mm vs. 4.09±0.22mm, p<0.001), maximum ONSD (5.63±0.55mm vs. 4.16±0.23mm, p<0.001), mean PI (1.53±0.16 vs. 1.45±0.20, p=0.01), and mean RI (0.76±0.07 vs. 0.73±0.04, p=0.01). The mean EDV, in contrast, was significantly higher in controls (8.55±3.09m/s vs. 7.17±2.61m/s, p=0.01). The two groups were comparable for the mean PSV (30.73±7.93m/s in cases vs. 32.27±10.39m/s in controls, p=0.36). Among the mentioned variables, the mean binocular ONSD was the most accurate parameter in detecting elevated ICP (sensitivity and specificity of 100%, cut-off point=4.53mm). The Doppler indices were only moderately accurate (sensitivity: 56.7−60%, specificity: 63.3−76.7%). ConclusionWhile the ultrasonographic mean binocular ONSD (>4.53mm) was completely accurate in detecting elevated ICP, color Doppler indices of the ophthalmic arteries were of limited value.