Abstract
AimSummarize the research progress of serum miRNAs in clinical application for early diagnosis and prognosis of ovarian cancer. MethodsReview of the recently published literature these was conducted. We selected reviews and clinical researches from different scientific societies.ResultsThe abnormal expression of serum miRNAs has a certain clinical value in theearly diagnosis of ovarian cancer. Many miRNAs, which are involved in regulating ovarian cancer cell growth, migration, and drug resistance, are also closely related to the patients’ survival rate and affect the prognostic condition of the patients. So the serum miRNAs may be useful diagnostic and prognostic biomarkers.Conclusions Studies have shown that serum miRNAs has the tumor specificity and high stability, enabling it has the potential for early diagnosis, prognosis and sensitivity to chemotherapy. However, the researches on serum miRNAs is still at the primary stage, further researches is needed for application of serum miRNAs in early diagnosis and prognosis of ovarian cancer.
Highlights
Ovarian cancer is one of the most common gynecologic malignancies, whose mortality rate is the highest among gynecologic tumors
Studies have shown that serum miRNAs has the tumor specificity and high stability, enabling it has the potential for early diagnosis, prognosis and sensitivity to chemotherapy
The researches on serum miRNAs is still at the primary stage, further researches is needed for application of serum miRNAs in early diagnosis and prognosis of ovarian cancer
Summary
The abnormal expression of serum miRNAs has a certain clinical value in the early diagnosis of ovarian cancer. Many miRNAs, which are involved in regulating ovarian cancer cell growth, migration, and drug resistance, are closely related to the patients’ survival rate and affect the prognostic condition of the patients. The serum miRNAs may be useful diagnostic and prognostic biomarkers
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