The Diagnosis of Perineural Invasion: A Crucial Factor in Novel Algorithm of Coexistence of Conventional and Nerve-Sparing Radical Hysterectomy.

Andrzej Skręt,Edyta Barnaś,Joanna Ewa Skręt-Magierło,Mariusz Książek,Joanna Bielatowicz,Bogusław Gawlik

doi:10.3390/diagnostics11081308

Andrzej Skręt, Edyta Barnaś + Show 4 more

Open Access

https://doi.org/10.3390/diagnostics11081308

Copy DOI

Journal: Diagnostics	Publication Date: Jul 21, 2021
Citations: 1	License type: CC BY 4.0

Affiliation: Rzeszów University

Abstract

Nerve-sparing radical hysterectomy (NSRH) was introduced to mitigate adverse effects associated with conventional radical hysterectomy (CRH) in cervical cancer. However, the introduction of NSRH was compromised by possible existence of perineural invasion (PNI). Additionally, the coexistence of NSRH and CRH is currently the fact. The aim of the study was to review the literature and attempt to construct a novel and preliminary PNI diagnostic algorithm that would establish the coexistence of NSRH and CRH in one system of early-stage cervical cancer (ESCC) surgical treatment. This algorithm takes into account the PNI risk factors and current and future diagnostic methods such as imaging and biopsy.

Highlights

Diagnostics 2021, 11, 1308. https://The surgical methods for cervical cancer treatment have been developing over the last120 years
In the Werheim era, at the beginning of radical hysterectomy (RH), the first compromise to be worked out was a radical technique connected with high mortality and cervical cancer, which used to be a fatal disease
Other side effects connected with RH were obvious infertility and high morbidity connected with wide lymph nodes dissection

Summary

Introduction

Diagnostics 2021, 11, 1308. https://The surgical methods for cervical cancer treatment have been developing over the last120 years. The surgical methods for cervical cancer treatment have been developing over the last. The introduction of each new surgical technique resulted in a new compromise that needed to be resolved. In the Werheim era, at the beginning of radical hysterectomy (RH), the first compromise to be worked out was a radical technique connected with high mortality and cervical cancer, which used to be a fatal disease. RH classifications were developed that gave the base to adjust the extent of dissection to stage cervical cancer (CC). Other side effects connected with RH were obvious infertility and high morbidity connected with wide lymph nodes dissection. These side effects of RH were partially diminished by the introduction of radical trachelectomy and the sentinel node technique

Objectives

Methods

Conclusion