Abstract
The differential diagnosis of isolated lymphadenopathy presenting as single or multiple tumors of the mediastinum found on x-ray examination of the chest may present considerable difficulty. The history, physical examination, skin sensitivity studies, bone marrow aspiration, peripheral blood examinations, and peripheral lymph node biopsies occasionally fail to establish a correct diagnosis. It has been an acceptable practice to treat such lesions empirically as lymphomas and to subject the patient to a trial of x-ray therapy.1” With subsequent decrease in size of the tumor over a period of one to two months, it was assumed that the diagnosis of lymphoma was correct and no additional studies were performed to determine the accurate histologic diagnosis. Since nonspecific lymphadenopathy, tuberculosis, histoplasmosis, and Boeck’s granulomas undergo spontaneous regression, or initially respond to radiation, such diagnostic radiation should be condemned. A series of cases considered to be lymphomas was studied at the Ohio State University Health Center in an attempt to point out the fallacy of trial radiation in patients with mediastinal lesions.
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