Abstract
Resistant hypertension (RH) in chronic renal failure patients is a difficult clinical problem. In hypertension patients without kidney diseases, the RH incidence is 1.9% to 12.8%. In chronic kidney disease (CKD)patients, the poorer renal function, the higher incidence of RH; the more severe proteinuria, the higher incidence of RH. The RH in CKD patients is mainly due to sympathetic nerve over- excitation, nitric oxide (NO) decrease, endothelin (ET) increase, angiotensin Ⅱ activity increase, insulin resistance, and hyperparathyroidism, etc. To control RH needs life style improvement, patient compliance evaluation and management, combined use of different kinds of antihypertensive drugs, and dialysis style change, and so on. If the above measures are not able to control RH, renal sympathetic denervation or baroreflex activation therapy can be considered. Key words: Resistant hypertension; Chronic renal failure; Pathogenesis; Treatment
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