Abstract
The influence of sex and the presence of gonads on the development of titre and specificity of antibodies in testosterone-immunised rabbits was investigated. The one-time, multiple-site, intradermal immunisation technique was applied. All rabbits (normal males and females, and castrated males) responded to immunisation with titres ranging between 1 16,000 and 1 240,000 . Female and castrated male rabbits tended to produce higher titres. Cross reactivity towards 5 α-dihydrotestosterone varied in all animals between 60 and 100% in an unpredictable fashion. The female rabbits showed higher cross reactivity towards androstenedione than the male animals, and this increased during immunisation. Serum testosterone levels in the normal male and female groups increased parallel to titre development.
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