Abstract
Background and objectiveChronic inflammatory is involved in the development of salt-sensitive hypertension and other cardiovascular diseases. PSGL-1 plays an important role in the inflammatory response.Methods and resultsIn this study, we used PSGL-1−/− and PSGL-1+/+ mice fed with high salt diet to measure the blood pressure, inflammatory response and vascular injury. We found that, in PSGL-1+/+ mice, high salt diet resulted in high blood pressure with the increased expression of serum inflammatory cytokines IL-6, IL-1β and TNFɑ, vascular injury markers MCP-1, ET-1, and VWF, and renal macrophages and T cells infiltration, and endothelium-dependent acetylcholine vasodilation dysfunction. However, the influence was not found in PSGL-1−/− mice. The deficiency of PSGL-1 prevented the increased adhesion of peripheral blood mononuclear cells to endothelial cells by high salt environment.ConclusionsOur results indicate that PSGL-1 is involved in the development of salt-sensitive hypertension via vascular inflammation and injury. The high salt induced inflammation may be initiated by leukocytes and endothelial cells adhesion through PSGL-1 binding with P-selectin or/and E-selectin.
Highlights
Background and objectiveChronic inflammatory is involved in the development of salt-sensitive hypertension and other cardiovascular diseases
Our results indicate that P-selectin glycoprotein ligand-1 (PSGL-1) is involved in the development of salt-sensitive hypertension via vascular inflammation and injury
The high salt induced inflammation may be initiated by leukocytes and endothelial cells adhesion through PSGL-1 binding with P-selectin or/and E-selectin
Summary
Background and objectiveChronic inflammatory is involved in the development of salt-sensitive hypertension and other cardiovascular diseases. Methods and results: In this study, we used PSGL-1−/− and PSGL-1+/+ mice fed with high salt diet to measure the blood pressure, inflammatory response and vascular injury. In PSGL-1+/+ mice, high salt diet resulted in high blood pressure with the increased expression of serum inflammatory cytokines IL-6, IL-1β and TNFɑ, vascular injury markers MCP-1, ET-1, and VWF, and renal macrophages and T cells infiltration, and endothelium-dependent acetylcholine vasodilation dysfunction. PSGL-1 plays an important role in the inflammatory response, Yang et al Cell Biosci (2018) 8:20 but whether it is involved in the pathological development of salt-sensitive hypertension remains unknown. In order to detect the role and mechanism of PSGL-1 in the development of salt-sensitive hypertension, we used PSGL-1 knockout (PSGL-1−/−) and wild-type (PSGL1+/+) mice fed with high salt diet to measure the blood pressure, inflammatory response and vascular injury
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