The development of relationship between DMD gene mutation and intelligence with Duchenne muscular dystrophy

Abstract

With the development of the molecular biology technic in recent years, the research about the relations between the type of gene mutation and the intelligence growth with the Duchenne muscular dystrophy (DMD) was developed.There are some connections in the intelligence and the type of gene mutation of the children with DMD. The children with DMD have lower intelligence when the mutation is after the 45 exon especially the 63 exon than before the 45 exon. It has more possibility to cause the lower intelligence when the the DMD gene mutation is closer to the end of 3'terminal. Key words: Duchenne muscular dystrophy; Dystrophin gene; Dystrophin protein; Dp-71; Intelligence