Abstract
Background: Hair loss is not a serious health problem but leads to decreased self- confidence, personality, and psychological problems. According to Thai traditional medical wisdom, Phyllanthus emblica has the property to prevent hair loss. Ethosomes are a drug delivery system, which can increase drug delivery to deep skin layers and enhance the effectiveness of the active ingredient. Objective: This research aims to develop ethosomes of Phyllanthus emblica extract with beneficial properties. Materials and Methods: Phyllanthus emblica was extracted by a maceration method with 95% ethanol as a solvent. The total phenolic content of the extracts was determined using the Folin-Ciocalteu method. The antioxidation activity was evaluated by DPPH assay. Ethosomes were formulated by a cold method and their properties were observed. Results: The results showed that the total phenolic content of Phyllanthus emblica extract was 406.37±2.39 mg GAE/g extract. The IC50 of antioxidant activity was 7.05±0.17 μg/ml. Ethosomes with 0.03% of Phyllanthus emblica extract, 2% of soya phosphatidylcholine, and 20% of ethanol had the highest percentage of entrapment efficiency (65.26%±1.80%). The ethosomes of Phyllanthus emblica extract was the spherical shape and white colloid. The particle size, polydispersity index, zeta potential, and pH of ethosomes were 0.43±0.00 μm, 0.44±0.03, -10.40±0.28 mV, and 4.06±0.03, respectively. Conclusion: The ethosomes of Phyllanthus emblica extract had good properties and area possible alternative product for hair loss prevention.
Highlights
Hair loss is a problem of concern for many people, both male and female
The results showed that the total phenolic content of Phyllanthus emblica extract was 406.37±2.39 mg GAE/g extract
Ethosomes with 0.03% of Phyllanthus emblica extract, 2% of soya phosphatidylcholine, and 20% of ethanol had the highest percentage of entrapment efficiency (65.26%±1.80%)
Summary
Hair loss is a problem of concern for many people, both male and female. Even though hair loss is not a serious health problem, it can lead in some cases too low self-confidence, psychological problems, and even impaired quality of life. Hair loss can be treated with discontinue behavior effect or using medicines such as finasteride and dutasteride which act as 5α- reductase inhibitors. They are effective on hair loss prevention the use of chemical products causes many side effects as well as altered libido, erectile dysfunction, and ejaculation disorder.[1]. Ethosomes is a novel drug delivery system that contains phospholipid, ethanol, and water. They are formed as vesicles containing P. emblica extract and can be used to increase the skin delivery to deep layers of skin, improve the systemic circulation, and enhancement of P. emblica extract effectiveness. This research aimed to develop ethosomes containing P. emblica which have good properties
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