Abstract
Current paper presents the results of the system development for intracranial implantation aimed on therapy and prevention of brain gliomas relapse. The main property of the system, in prospective, will be to direct the growth of glioma cells localized in the region adjacent to the site of the removed tumor along the fi bers towards the proximal part of the fiber-optic scaffold (neuroport). Such approach will allow carrying out cells diagnostics by the photoluminescence signal and provide subsequent destruction of malignant cells by photodynamic action. Besides, this system could be used for monitoring the processes occurring in the probed area in order to control the possible relapses. The localization of cells along the fi ber structures covered with gelatin compound, which is the source of amino acids during cultivation, was shown during the glioma cells growth dynamics study. Moreover, four different designs of intracranial scaffold models, serving as ports for diagnostic and therapeutic laser radiation delivery, were developed and successfully tested in the framework of the research. The results obtained on the rats brain with induced tumors (glioma C6) after neuroport implantation demonstrate sufficiently intense fluorescence in the tumor bed after intravenous injection of the nonmetallic sulfonated phthalocyanine based photosensitizer, and a pronounced photodynamic effect leading to total destruction of the tumor. In this way, the results of this study open the prospects of creating the neuroport with an internal fi ber structure that focuses the glioma cells growth.
Highlights
The general treatment of patients with glial brain tumors is characterized by a comprehensive approach that includes surgical removal, radio- and chemotherapy [1, 2]
It is significant to note that at present there are scaffolds that are placed into the tumor bed after resection. This therapy approach is based on the prolonged action of chemotherapeutic drug, which is gradually released from the scaffold, affecting the tumor cells remaining after surgical intervention thereby preventing recurrence [6,7]
Results of in vitro studies The growth processes of C6 malignant glioma cells and their localization on the optical fibers surface, which in the plans will constitute the internal structure of the brain scaffold, were visualized by laser scanning confocal microscopy method
Summary
The general treatment of patients with glial brain tumors is characterized by a comprehensive approach that includes surgical removal, radio- and chemotherapy [1, 2]. It is significant to note that at present there are scaffolds that are placed into the tumor bed after resection This therapy approach is based on the prolonged action of chemotherapeutic drug, which is gradually released from the scaffold, affecting the tumor cells remaining after surgical intervention thereby preventing recurrence [6,7]. Such way of brain neoplasms therapy is considered the most effective among the currently existing ones, some glioma types are resistant to chemo- and radiotherapy, which does not allow this method to be universal. Photodynamic therapy is the most appropriate and effective method for providing a destructive impact on pathological tissues due to the fiber-optic internal structure of the scaffold
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