Abstract
Abstract Investigations by using animal models offer a useful tool to study the pathogenesis and cure of several incurable human diseases. The laboratory animal science in this field was established about 20 years ago in Japan. This paper describes the outline of its history and the characteristics of each animal model which has been studied extensively and will also be studied in the future in Japan. Some results on dystrophic chicken and gracile axonal dystrophic (gad) mouse which were recently obtained in our laboratory are discussed.
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