Abstract
This research is a study on the development of innovative clay mask mixed with the Acanthus ebracteatus Vahl extract product. The purposes of this research are as follows. Firstly, the research is to develop a clay mask product mixed with natural extracts from the Acanthus ebracteatus Vahl. Secondly, it is aimed to study on the antioxidant activity, anti-inflammatory effect, antimicrobial effect and total Phenolic contents of the Acanthus ebracteatus Vahl extracts. Thirdly, it is tostudy stability of the product. Finally, the research is to study on the calculation of suitable product formulations for clay products mixed with Acanthus ebracteatus Vahl extracts. By starting from the selection of raw materials, the extracts are prepared to determine the total phenolic content. Later, 2,2-diphenyl-1-picrylhydrazyl (DPPH) Assay method is conducted for antioxidant activity test, followed by anti-inflammatory effect test (Nitric oxide production inhibitory activity test, inhibition of LPS-induced TNF-α secretion test and Anti-inflammatory activity test (COX-2). Afterwards, a suitable formulation is developed. The test for the safety and physical properties of the product is then carried out followed by the skin irritation test in a group of 10 volunteers in order to ensure that the clay mask product containing Acanthus ebracteatus Vahl extracts is effective and safe. From the results of the product stability study, the findings indicated that the clay mask product containing Acanthus ebracteatus Vahl extracts did not show any phase separation. The irritation test in 10 volunteers after 12 hours of using the product showed no sign of allergic reaction, itching or irritation. Toxicity test results found no cytotoxicity. The anti-inflammatory effect test was found to have potent anti-inflammatory properties, when tested in the RAW 264.7 macrophage cell. This study is only for the development of an innovative product of skin clay mask mixed with the Acanthus ebracteatus Vahl extracts.
Highlights
Clay has been used for many purposes
*Corresponding author: E-mail: narin.ka@ssru.ac.th; Kakatum et al.; JPRI, 33(59B): 364-370, 2021; Article no.JPRI.76841 the results of the product stability study, the findings indicated that the clay mask product containing Acanthus ebracteatus Vahl extracts did not show any phase separation
No skin irritation when used of saline solution, clay mask base and clay mask mixed with Acanthus ebracteatusVahl Leaf extracts (Tables 5, 6 and 7)
Summary
Clay has been used for many purposes. Clay therapy has played a major role in the treatment and prevention of diseases or enhancement the beauty of the body since ancient times. There are no studies and use in promoting, preserving, and preventing disease in accordance with the government's policy that supports the use and reliance on nature, create a better quality of life and improve the level of sustainable living. The Acanthus ebracteatus Vahl is a plant that is commonly seen, often up along rivers and canals (The Botanical Garden Organization, n.d.) It is a plant that has many medicinal properties such as helping to reduce inflammation of acne containing antioxidants that are good for skin. The Acanthus ebracteatus Vahl has been used to make shower gel products (Wongsarn, 2000). In regard to the aforementioned properties, the researcher is interested in using ihe Acanthus ebracteatus Vahl in this research to improve the efficacy of the products. The research will generate income, expand tourist attractions and further improve community potential
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