Abstract
Summary Injection of rabbits with certain aqueous preparations of heterologous thyroglobulin results in the production of both thyroiditis and antibody to rabbit thyroglobulin. Injections of bovine and human thyroglobulin were effective, whereas injections of porcine thyroglobulin were relatively ineffective. Injections of a mixture of several thyroglobulins were more effective than injections of individual thyroglobulins. The thyroid lesions which developed in some of the rabbits injected with the mixture were very extensive, involving most of the thyroid tissue. Rabbits immunized with bovine thyroglobulin were responsive to injections of rabbit thyroglobulin given as late as 5 months after the injections of bovine thyroglobulin. However, the ability of these rabbits to respond to rabbit thyroglobulin decreased with time. The antibody produced as a result of the subsequent injections of rabbit thyroglobulin was directed to only the determinants on rabbit thyroglobulin related to determinants on bovine thyroglobulin. The similarities between the induction of autoimmune thyroiditis and termination of acquired immunologic unresponsiveness following injections of cross-reacting and altered antigens are discussed.
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