Abstract
The goal of this study was to create and test various in-situ gel formulas for administering posaconazole to the eye to treat fungal keratitis. They used an in-situ gelling method to help posaconazole stay in the eye mucosa longer, which made it easier for the body to use. To make in-situ gel preparations, polymers such as sodium alginate, poloxamer 407, and poloxamer 188 were used in a cold method. Finally, there was 0.2% (w/w) posaconazole in the mixtures. The pH, drug content, viscosity, gelling capacity, and temperature at which the solution turns into a gel were all checked on the recipes. It was between 32 and 34℃ when each blend turned into a gel. There was about the same amount of drugs in all of them. It was also worked out how much of the antifungal and in-vitro drugs these mixtures would release. Everyone in the drug release study showed signs of long-lasting release. To sum up, in-situ gels that contain posaconazole could be a good way to use optical drug delivery to change how fungus diseases act.
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