Abstract

AbstractThere is a need for an in situ assay to quantify tissue reactivity to sustained release of bFGF to better understand and control growth factor-induced angiogenesis. To this end we have adapted the alginate/heparin-sepharose release system for use in the mouse dorsal skinfold chamber. A mathematical model was used to predict the time dependence of bFGF release as a function of bFGF loading, heparin concentration, and device geometry. The model predictions agreed well with previously reported in vitro data. In vivo studies to correlate blood vessel growth as a function of release rate are in progress.

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