Abstract
This paper presents a novel wireless Love-wave-based biosensor using apolymethyl methacrylate (PMMA) waveguide and protein A receptor layers on a41° YX LiNbO3 piezoelectric substrate for immunoglobulin G (IgG) detection. A 440 MHz reflective delayline composed of single-phase unidirectional transducers (SPUDTs) and threeshorted grating reflectors was fabricated as the sensor element. A theoreticalmodeling was performed to describe the wave propagation of Love wave devices on a41° YX LiNbO3 piezoelectric substrate with large piezoelectricity. The fabricated devices were wirelesslycharacterized by using the network analyzer as the reader unit. The resultant reflectionpeaks showed large signal/noise ratio, sharp peaks, and few spurious signals. The binding ofthe IgG to the protein A receptor layer induced large phase shifts of the reflection peaksdue to the mass loading effect. Good linearity, reproducibility, and high sensitivity wereobserved in the IgG concentration range 1–65 nM. Unique advantages such as highsensitivity and a simple wireless measurement method over other currently availablebiosensors are also presented.
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