The development of a versatile and expeditious route to pet imaging ligands and its potential applications to prostate cancer treatment and diagnosis

Abstract

Chapter 1 of this thesis describes the development of potential PET imaging ligands using microwave thermolysis. Work described in this chapter was primarily investigated at Northeastern University under the supervision of Professor Graham B. Jones. The microwave accelerated fluorodenitration reaction using KF/K222, TBAF/THF (DMSO) and anhydrous TBAF is discussed. The applications of such reactions to commercial pharmaceuticals and potential PET imaging agents are demonstrated. In addition, a novel route to access arenes with a fluoro alkyl tether is explored. The development of the tandem Hiyama coupling fluoro alkylation reaction is discussed.