Abstract
AbstractThe aerodynamic diameter of an airborne particle is the key property in determining its respiratory deposition. Two particles may differ in their shape, size, and/or density and still be aerodynamically indistinguishable because they have similar behavior in a moving airstream. A cascade impactor has been used to measure the range of aerodynamic diameters for drug particles in an aerosol spray product. The two terms associated with aerodynamic particle sizing are Mass Median Aerodynamic Diameter (MMAD) and the Geometric Standard Deviation (GSD). Both terms are determined from the visual fit of a straight line to data manually plotted on log-probability paper. The plotting of this data is a time consuming activity and the fit of the line to the data can be very subjective.Although this technique is an excellent candidate for computerization, it cannot be done directly since the probability axis is an integral function not easily adaptable to the computer packages generally used in the laboratory. A...
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