Abstract
The two-dimensional (2D) leaf-like zeolitic imidazolate framework-L (Zn) (ZIF-L (Zn)) was synthesized using a simple method in this study. The ZIF-L (Zn) was characterized using various techniques, such as FE-SEM, XRD, FT-IR, elemental mapping and EDX. The ZIF-L (Zn) was utilized to modify the surface of screen-printed graphite electrode (ZIF-L (Zn)/SPGE) to detect uric acid (UA). The sensor exhibited electrocatalytic behavior for uric acid in phosphate buffer solutions (PBS, 0.1 M), with a linear dependence between the current response and uric acid concentration in the dynamic range from 0.1 μM to 900.0 μM, a low limit of detection (LOD) of 0.04 μM, and good sensitivity of 0.0393 μA/μM under optimized experimental conditions. The ZIF-L (Zn)/SPGE sensor was successfully applied for uric acid determination in the presence of dopamine (DA) and theophylline (Thp) without any interference. The proposed electrode exhibits well-separated oxidation peaks at potentials of 139, 260 and 900 mV for dopamine, uric acid, and theophylline, respectively. In addition, the practical application of the fabricated sensor was demonstrated by detecting dopamine, uric acid, and theophylline in real samples.
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